Progression of Chronic Kidney Disease: The Role of Blood Pressure Control, Proteinuria, and Angiotensin-Converting Enzyme Inhibition: A Patient-Level Meta-Analysis
Aga Khan University · The University of Texas Southwestern Medical Center · +3 more institutions
Abstract
BACKGROUND: Angiotensin-converting enzyme (ACE) inhibitors reduce blood pressure and urine protein excretion and slow the progression of chronic kidney disease. PURPOSE: To determine the levels of blood pressure and urine protein excretion associated with the lowest risk for progression of chronic kidney disease during antihypertensive therapy with and without ACE inhibitors. DATA SOURCES: 11 randomized, controlled trials comparing the efficacy of antihypertensive regimens with or without ACE inhibitors for patients with predominantly nondiabetic kidney disease. STUDY SELECTION: MEDLINE database search for English-language studies published between 1977 and 1999. DATA EXTRACTION: Data on 1860 nondiabetic…
Citation impact
- FWCI
- 23.62
- Percentile
- 100%
- References
- 42
Authors
11- THTazeen H. JafarCorresponding
Aga Khan University, The University of Texas Southwestern Medical Center, United States Military Academy, University of Groningen, Southwestern Medical Center
- PCPaul C. Stark
United States Military Academy, Southwestern Medical Center, The University of Texas Southwestern Medical Center, Aga Khan University, University of Groningen
- CHChristopher H. Schmid
Southwestern Medical Center, Aga Khan University, United States Military Academy, The University of Texas Southwestern Medical Center, University of Groningen
- MLMarcia Landa
The University of Texas Southwestern Medical Center, United States Military Academy, University of Groningen, Aga Khan University, Southwestern Medical Center
- GMGiuseppe Maschio
Aga Khan University, Southwestern Medical Center, United States Military Academy, University of Groningen, The University of Texas Southwestern Medical Center
Topics & keywords
- Medicine
- Kidney disease
- Blood pressure
- Proteinuria
- Internal medicine
- Renal function
- Excretion
- Angiotensin-converting enzyme
- Good health and well-being