New genetic loci link adipose and insulin biology to body fat distribution

Shungin, Dmitry; GLGC, The; ICBP, The; Study, The LifeLines Cohort; Investigators, The MAGIC; Winkler, Thomas W.; Croteau‐Chonka, Damien C.; Ferreira, Teresa; Locke, Adam E.; Mägi, Reedik; Strawbridge, Rona J.; Pers, Tune H.; Fischer, Krista; Justice, Anne E.; Workalemahu, Tsegaselassie; Wu, Joseph; Buchkovich, Martin L.; Heard‐Costa, Nancy L.; Roman, Tamara S.; Drong, Alexander; Song, Ci; Gustafsson, Stefan; Day, Felix R.; Esko, Tõnu; Fall, Tove; Kutalik, Zoltán; Luan, Jian’an; Randall, Joshua C.; Scherag, André; Vedantam, Sailaja; Wood, Andrew R.; Chen, Jin; Fehrmann, Rudolf S.N.; Karjalainen, Juha; Kahali, Bratati; Liu, Ching‐Ti; Schmidt, Ellen M.; Absher, Devin; Amin, Najaf; Anderson, Denise; Beekman, Marian; Bragg‐Gresham, Jennifer L.; Buyske, Steven; Demirkan, Ayşe; Ehret, Georg; Feitosa, Mary F.; Goel, Anuj; Jackson, Anne; Johnson, Toby; Kleber, Marcus E.; Kristiansson, Kati; Mangino, Massimo; Leach, Irene Mateo; Medina‐Gómez, Carolina; Palmer, Cameron D.; Pasko, Dorota; Pechlivanis, Sonali; Peters, Marjolein J.; Prokopenko, Inga; Stančáková, Alena; Sung, Yun Ju; Tanaka, Toshiko; Teumer, Alexander; Vliet‐Ostaptchouk, Jana V. van; Yengo, Loïc; Zhang, Weihua; Albrecht, Eva; Ärnlöv, Johan; Arscott, Gillian M.; Bandinelli, Stefania; Barrett, Amy; Bellis, Claire; Bennett, Amanda J.; Berne, Christian; Blüher, Matthias; Böhringer, Stefan; Bonnet, Fabrice; Böttcher, Yvonne; Bruinenberg, Marcel; Carba, Delia B.; Caspersen, Ida Henriette; Clarke, Robert; Daw, E. Warwick; Deelen, Joris; Deelman, Ewa; Delgado, Graciela; Doney, Alex S. F.; Eklund, Niina; Erdos, Michael R.; Estrada, Karol; Eury, Elodie; Friedrich, Nele; Garcia, Melissa E.; Giedraitis, Vilmantas; Gigante, Bruna; Go, Alan S.; Golay, Alain; Grallert, Harald; Grammer, Tanja B.; Gräßler, Jürgen; Grewal, Jagvir; Groves, Christopher J.; Haller, Toomas; Hallmans, Göran; Hartman, Catharina A.; Hassinen, Maija; Hayward, Caroline; Heikkilä, Kauko; Herzig, Karl‐Heinz; Helmer, Quinta; Hillege, Hans L.; Holmen, Oddgeir L.; Hunt, Steven C.; Isaacs, Aaron; Ittermann, Till; James, Alan L.; Johansson, Ingegerd; Juliusdottir, Thorhildur; Kalafati, Ioanna Panagiota; Kinnunen, Leena; Köenig, Wolfgang; Kooner, Ishminder K.; Kratzer, Wolfgang; Lamina, Claudia; Leander, Karin; Lee, Sang; Lichtner, Peter; Lind, Lars; Lindström, Jaana; Lobbens, Stéphane; Lorentzon, Mattias; Mach, François; Magnusson, Patrik K. E.; Mahajan, Anubha; McArdle, Wendy L.; Menni, Cristina; Merger, Sigrun; Mihailov, Evelin; Milani, Lili; Mills, Rebecca; Moayyeri, Alireza; Monda, Keri L.; Mooijaart, Simon P.; Mühleisen, Thomas W.; Mulas, Antonella; Müller, Gabriele; Müller‐Nurasyid, Martina; Nagaraja, Ramaiah; Nalls, Michael A.; Narisu, Narisu; Glorioso, Nicola; Nolte, Ilja M.; Olden, Matthias; Rayner, Nigel W.; Renström, Frida; Ried, Janina S.; Robertson, Neil R.; Rose, Lynda M.; Sanna, Serena; Scharnagl, Hubert; Scholtens, Salome; Sennblad, Bengt; Seufferlein, Thomas; Sitlani, Colleen M.; Smith, Albert V.; Stirrups, Kathleen; Stringham, Heather M.; Sundström, Johan; Swertz, Morris A.; Swift, Amy J.; Syvänen, Ann‐Christine; Tayo, Bamidele O.; Thorand, Barbara; Þorleifsson, Guðmar; Tomaschitz, Andreas; Troffa, Chiara; Oort, Floor V. A. van; Verweij, Niek; Vonk, Judith M.; Waite, Lindsay L.; Wennauer, Roman; Wilsgaard, Tom; Wojczynski, Mary K.; Wong, Andrew; Zhang, Qunyuan; Zhao, Wei; Brennan, Eoin; Choi, Murim; Eriksson, Per; Folkersen, Lasse; Franco-Cereceda, Anders; Gharavi, Ali G.; Hedman, Åsa K.; Hivert, Marie‐France; Huang, Jinyan; Kanoni, Stavroula; Karpe, Fredrik; Keildson, Sarah; Kiryluk, Krzysztof; Liang, Liming; Lifton, Richard P.; Ma, Baoshan; McKnight, Amy Jayne; McPherson, Ruth; Metspalu, Andres; Min, Josine L.; Moffatt, Miriam F.; Montgomery, Grant W.; Murabito, Joanne M.; Nicholson, George; Nyholt, Dale R.; Olsson, Christian; Perry, John R. B.; Reinmaa, Eva; Salem, Rany M.; Sandholm, Niina; Schadt, Eric E.; Scott, Robert A.; Stolk, Lisette; Vallejo, Edgar E.; Westra, Harm-Jan; Zondervan, Krina T.; Amouyel, Philippe; Arveiler, Dominique; Bakker, Stephan J. L.; Beilby, John; Bergman, Richard N.; Blangero, John; Brown, Morris J.; Burnier, Michel; Campbell, Harry; Chakravarti, Aravinda; Chines, Peter S.; Claudi-Boehm, Simone; Collins, Francis S.; Crawford, Dana C.; Danesh, John; Fairé, Ulf dé; Geus, Eco J. C. de; Dörr, Marcus; Erbel, Raimund; Eriksson, Johan G.; Farrall, Martin; Ferrannini, Ele; Ferrières, Jean; Forouhi, Nita G.; Forrester, Terrence; Franco, Oscar H.; Gansevoort, Ron T.; Gieger, Christian; Guðnason, Vilmundur; Haiman, Christopher A.; Harris, Tamara B.; Hattersley, Andrew T.; Heliövaara, Markku; Hicks, Andrew A.; Hingorani, Aroon D.; Hoffmann, Wolfgang; Hofman, Albert; Homuth, Georg; Humphries, Steve E.; Hyppönen, Elina; Illig, Thomas; Järvelin, Marjo‐Riitta; Johansen, Berit; Jousilahti, Pekka; Jula, Antti; Kaprio, Jaakko; Kee, Frank; Keinänen‐Kiukaanniemi, Sirkka; Kooner, Jaspal S.; Kooperberg, Charles; Kovács, Péter; Kraja, Aldi T.; Kumari, Meena; Kuulasmaa, Kari; Kuusisto, Johanna; Lakka, Timo A.; Langenberg, Claudia; Marchand, Loı̈c Le; Lehtimäki, Terho; Lyssenko, Valeriya; Männistö, Satu; Marette, André; Matise, Tara C.; McKenzie, Colin A.; McKnight, Barbara; Musk, Arthur W.; Möhlenkamp, Stefan; Morris, Andrew D.; Nelis, Mari; Ohlsson, Claes; Oldehinkel, Albertine J.; Ong, Ken K.; Palmer, Lyle J.; Penninx, Brenda W.J.H.; Peters, Annette; Pramstaller, Peter P.; Raitakari, Olli; Rankinen, Tuomo; Rao, D. C.; Rice, Treva; Ridker, Paul M.; Ritchie, Marylyn D.; Rudan, Igor; Salomaa, Veikko; Samani, Nilesh J.; Saramies, Jouko; Sarzynski, Mark A.; Schwarz, Peter; Shuldiner, Alan R.; Staessen, Jan A.; Steinthórsdóttir, Valgerður; Stolk, Ronald P.; Strauch, Konstantin; Tönjes, Anke; Tremblay, Angelo; Tremoli, Elena; Vohl, Marie‐Claude; Völker, Uwe; Vollenweider, Péter; Wilson, James F.; Witteman, Jacqueline C.M.; Adair, Linda S.; Bochud, Murielle; Boehm, Bernhard O.; Bornstein, Stefan R.; Bouchard, Claude; Cauchi, Stéphane; Caulfield, Mark J.; Chambers, John C.; Chasman, Daniel I.; Cooper, Richard S.; Dedoussis, George; Ferrucci, Luigi; Froguel, Philippe; Grabe, Hans J.; Hamsten, Anders; Hui, Jennie; Hveem, Kristian; Jöckel, Karl‐Heinz; Kivimäki, Mika; Kuh, Diana; Laakso, Markku; Liu, Ching‐Ti; März, Winfried; Munroe, Patricia B.; Njølstad, Inger; Oostra, Ben A.; Palmer, Colin N. A.; Pedersen, Nancy L.; Perola, Markus; Përusse, Louis; Peters, Ulrike; Power, Chris; Quertermous, Thomas; Rauramaa, Rainer; Rivadeneira, Fernando; Saaristo, Timo; Saleheen, Danish; Sinisalo, Juha; Slagboom, P. Eline; Snieder, Harold; Spector, Tim D.; Þorsteinsdóttir, Unnur; Stümvoll, Michael; Tuomilehto, Jaakko; Uitterlinden, André G.; Uusitupa, Matti; Harst, Pim van der; Veronesi, Giovanni; Walker, Mark; Wareham, Nicholas J.; Watkins, Hugh; Wichmann, H‐Erich; Abecasis, Gonçalo R.; Assimes, Themistocles L.; Berndt, Sonja I.; Boehnke, Michael; Borecki, Ingrid B.; Deloukas, Panos; Franke, Lude; Frayling, Timothy M.; Groop, Leif C.; Hunter, David J.; Kaplan, Robert C.; O’Connell, Jeffrey R.; Qi, Lu; Schlessinger, David; Strachan, David P.; Stefánsson, Kāri; Duijn, Cornelia M. van; Willer, Cristen J.; Visscher, Peter M.; Yang, Jian; Hirschhorn, Joel N.; Zillikens, M. Carola; McCarthy, Mark I.; Speliotes, Elizabeth K.; North, Kari E.; Fox, Caroline S.; Barroso, Inês; Franks, Paul W.; Ingelsson, Erik; Heid, Iris M.; Loos, Ruth J. F.; Cupples, L. Adrienne; Morris, Andrew P.; Lindgren, Cecilia M.; Mohlke, Karen L.

doi:10.1038/nature14132

reviewNatureFeb 10, 2015BRONZE OA

New genetic loci link adipose and insulin biology to body fat distribution

DSDmitry ShunginTGThe GLGCTIThe ICBPTLThe LifeLines Cohort StudyTMThe MAGIC Investigators

Lund University · Skåne University Hospital · +234 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

No abstract available for this paper.

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1,707

total citations

FWCI: 132.75
Percentile: 100%
References: 102

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Authors

410

DS
Dmitry ShunginCorresponding
Lund University, Skåne University Hospital, Umeå University
TG
The GLGC
University of Regensburg
TI
The ICBP
Brigham and Women's Hospital, Harvard University
TL
The LifeLines Cohort Study
Centre for Human Genetics, University of Oxford
TM
The MAGIC Investigators
University of Michigan

Topics & keywords

Topics

Keywords

Adipose tissue
Biology
Link (geometry)
Genetics
Insulin
Endocrinology
Computer science

UN Sustainable Development Goals

Good health and well-being

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