Does the Use of Chitosan Contribute to Oxalate Kidney Stone Formation?
Universidade Federal do Rio Grande do Norte · Universidade Federal do Paraná · +1 more institution
Abstract
Chitosan is widely used in the biomedical field due its chemical and pharmacological properties. However, intake of chitosan results in renal tissue accumulation of chitosan and promotes an increase in calcium excretion. On the other hand, the effect of chitosan on the formation of calcium oxalate crystals (CaOx) has not been described. In this work, we evaluated the antioxidant capacity of chitosan and its interference in the formation of CaOx crystals in vitro. Here, the chitosan obtained commercially had its identity confirmed by nuclear magnetic resonance and infrared spectroscopy. In several tests, this chitosan showed low or no antioxidant activity. However, it also showed excellent copper-chelating…
Citation impact
- FWCI
- 1.70
- Percentile
- 100%
- References
- 52
Authors
5- MFMoacir Fernandes Queiroz
Universidade Federal do Rio Grande do Norte
- KRKaroline Rachel Teodosio de Melo
Universidade Federal do Rio Grande do Norte
- DSDiego Sabry
Universidade Federal do Paraná, Universidade Federal de São Paulo
- GLGuilherme L. Sassaki
Universidade Federal do Paraná
- HAHugo Alexandre Oliveira RochaCorresponding
Universidade Federal do Rio Grande do Norte
Topics & keywords
- Chitosan
- Calcium oxalate
- Kidney stones
- In vitro
- Antioxidant
- Oxalate
- Chemistry
- In vivo