Vacuum-Assisted Closure: Microdeformations of Wounds and Cell Proliferation
Massachusetts Institute of Technology · Boston Children's Hospital · +3 more institutions
Abstract
The mechanism of action of the Vacuum Assisted Closure Therapy (VAC; KCI, San Antonio, Texas), a recent novel innovation in the care of wounds, remains unknown. In vitro studies have revealed that cells allowed to stretch tend to divide and proliferate in the presence of soluble mitogens, whereas retracted cells remain quiescent. The authors hypothesize that application of micromechanical forces to wounds in vivo can promote wound healing through this cell shape-dependent, mechanical control mechanism. The authors created a computer model (finite element) of a wound and simulated VAC application. Finite element modeling is commonly used to engineer complex systems by breaking them down into simple discrete…
Citation impact
- FWCI
- 22.24
- Percentile
- 100%
- References
- 30
Authors
6- VSVishal SaxenaCorresponding
Massachusetts Institute of Technology, Boston Children's Hospital, Harvard University, Brigham and Women's Hospital, Massachusetts General Hospital
- CHChao‐Wei Hwang
Massachusetts General Hospital, Boston Children's Hospital, Harvard University, Brigham and Women's Hospital, Massachusetts Institute of Technology
- SHSui Huang
Massachusetts General Hospital, Massachusetts Institute of Technology, Brigham and Women's Hospital, Boston Children's Hospital, Harvard University
- QEQuentin Eichbaum
Boston Children's Hospital, Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, Massachusetts Institute of Technology
- DEDonald E. Ingber
Brigham and Women's Hospital, Boston Children's Hospital, Massachusetts Institute of Technology, Harvard University, Massachusetts General Hospital
Topics & keywords
- Wound healing
- Finite element method
- Deformation (meteorology)
- Medicine
- In vivo
- Angiogenesis
- Wound closure
- Cell biology
- Industry, innovation and infrastructure