articleNew England Journal of MedicineJul 12, 2006BRONZE OA

Effects of Raloxifene on Cardiovascular Events and Breast Cancer in Postmenopausal Women

University of California, San Francisco · University of California San Diego · +5 more institutions

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Abstract

Background

The effect of raloxifene, a selective estrogen-receptor modulator, on coronary heart disease (CHD) and breast cancer is not established.

Methods

We randomly assigned 10,101 postmenopausal women (mean age, 67.5 years) with CHD or multiple risk factors for CHD to 60 mg of raloxifene daily or placebo and followed them for a median of 5.6 years. The two primary outcomes were coronary events (i.e., death from coronary causes, myocardial infarction, or hospitalization for an acute coronary syndrome) and invasive breast cancer.

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