Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease
Novartis (Switzerland) · Munich University of Applied Sciences · +3 more institutions
Abstract
The neurodegeneration observed in Alzheimer's disease has been associated with synaptic dismantling and progressive decrease in neuronal activity. We tested this hypothesis in vivo by using two-photon Ca2+ imaging in a mouse model of Alzheimer's disease. Although a decrease in neuronal activity was seen in 29% of layer 2/3 cortical neurons, 21% of neurons displayed an unexpected increase in the frequency of spontaneous Ca2+ transients. These "hyperactive" neurons were found exclusively near the plaques of amyloid beta-depositing mice. The hyperactivity appeared to be due to a relative decrease in synaptic inhibition. Thus, we suggest that a redistribution of synaptic drive between silent and hyperactive…
Citation impact
- FWCI
- 20.97
- Percentile
- 100%
- References
- 41
Authors
9- MAMarc Aurel Busche
Novartis (Switzerland), Munich University of Applied Sciences, Center for Integrated Protein Science Munich, Novartis Institutes for BioMedical Research, Ludwig-Maximilians-Universität München
- GEGerhard Eichhoff
Novartis (Switzerland), Munich University of Applied Sciences, Center for Integrated Protein Science Munich, Novartis Institutes for BioMedical Research, Ludwig-Maximilians-Universität München
- HAHelmuth Adelsberger
Novartis (Switzerland), Munich University of Applied Sciences, Center for Integrated Protein Science Munich, Novartis Institutes for BioMedical Research, Ludwig-Maximilians-Universität München
- DADorothée Abramowski
Novartis (Switzerland), Munich University of Applied Sciences, Center for Integrated Protein Science Munich, Novartis Institutes for BioMedical Research, Ludwig-Maximilians-Universität München
- KWKarl‐Heinz Wiederhold
Novartis (Switzerland), Munich University of Applied Sciences, Center for Integrated Protein Science Munich, Novartis Institutes for BioMedical Research, Ludwig-Maximilians-Universität München
Topics & keywords
- Neuroscience
- Neurodegeneration
- Alzheimer's disease
- Premovement neuronal activity
- Disease
- Chemistry
- Biology
- Medicine
- Good health and well-being