Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
Broad Institute · Harvard University · +6 more institutions
Abstract
New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D-in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1-and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory…
Citation impact
- FWCI
- 220.54
- Percentile
- 100%
- References
- 28
Authors
67- RSRicha SaxenaCorresponding
Broad Institute, Harvard University, Massachusetts General Hospital, Center for Human Genetics, Massachusetts Institute of Technology
- BFBenjamin F. Voight
Broad Institute, Harvard University, Massachusetts General Hospital, Center for Human Genetics, Massachusetts Institute of Technology
- VLValeriya Lyssenko
Broad Institute, Harvard University, Massachusetts General Hospital, Center for Human Genetics, Massachusetts Institute of Technology
- NPNoël P. Burtt
Broad Institute, Harvard University, Massachusetts General Hospital, Center for Human Genetics, Massachusetts Institute of Technology
- PIPaul I. W. de Bakker
Broad Institute, Harvard University, Massachusetts General Hospital, Center for Human Genetics, Massachusetts Institute of Technology
Topics & keywords
- Biology
- Single-nucleotide polymorphism
- Genetics
- Genome-wide association study
- Genetic association
- Type 2 diabetes
- Intron
- SNP
- Good health and well-being