Surface hydration: Principles and applications toward low-fouling/nonfouling biomaterials

Surface resistance to nonspecific protein adsorption, cell/bacterial adhesion, and biofilm formation is critical for the development and performance of biomedical and analytical devices. Significant needs and efforts have been made in the development of biocompatible and bioactive materials for antifouling surfaces, but much of the work retains an empirical flavor due to the complexity of experiments and the lack of robust theoretical models. In this review, two major classes of nonfouling materials (i.e. hydrophilic and zwitterionic materials) and associated basic nonfouling mechanisms and practical examples are discussed. Highly hydrated chemical groups with optimized physical properties of the surface,…

• NN
  National Natural Science Foundation of China

  Awards: 20874085, 20974095
• AC
  American Chemical Society Petroleum Research Fund

  Award: 48188-G5