articleProceedings of the National Academy of SciencesJun 27, 2003GREEN OA

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

MPMary‐Elizabeth PattiAJAtul J. ButteSCSarah CrunkhornKCKenneth CusiRBRachele Berria

Joslin Diabetes Center · Beth Israel Deaconess Medical Center · +1 more institution

PubMed
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Abstract

Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, glycogen synthesis, and accumulation of intramyocellular triglycerides have all been linked with insulin resistance, but no specific defect responsible for insulin resistance and DM has been identified in humans. To identify genes potentially important in the pathogenesis of DM, we analyzed gene expression in skeletal muscle from healthy metabolically characterized nondiabetic (family history negative and positive for DM) and diabetic Mexican-American…

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Topics & keywords

Topics
Keywords
  • Insulin resistance
  • NRF1
  • Endocrinology
  • Internal medicine
  • Biology
  • Insulin
  • Diabetes mellitus
  • Skeletal muscle
UN Sustainable Development Goals
  • Good health and well-being
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