The diploid genome sequence of Candida albicans
University of Minnesota · Chiba University · +2 more institutions
Abstract
We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.
Citation impact
- FWCI
- 32.09
- Percentile
- 100%
- References
- 25
Authors
12- TJTed JonesCorresponding
University of Minnesota, Chiba University, University of California, San Francisco
- NANancy A. Federspiel
University of Minnesota, Chiba University, University of California, San Francisco, New York Genome Center
- HCHiroji Chibana
University of Minnesota, Chiba University, University of California, San Francisco
- JDJan Dungan
University of Minnesota, Chiba University, University of California, San Francisco
- SKSue Kalman
University of Minnesota, Chiba University, University of California, San Francisco, New York Genome Center
Topics & keywords
- Ploidy
- Biology
- Genome
- Shotgun sequencing
- Whole genome sequencing
- Candida albicans
- Genetics
- Loss of heterozygosity