The clinical utility of C‐peptide measurement in the care of patients with diabetes

C-peptide is produced in equal amounts to insulin and is the best measure of endogenous insulin secretion in patients with diabetes. Measurement of insulin secretion using C-peptide can be helpful in clinical practice: differences in insulin secretion are fundamental to the different treatment requirements of Type 1 and Type 2 diabetes. This article reviews the use of C-peptide measurement in the clinical management of patients with diabetes, including the interpretation and choice of C-peptide test and its use to assist diabetes classification and choice of treatment. We provide recommendations for where C-peptide should be used, choice of test and interpretation of results. With the rising incidence of Type…

• CO
  Centre of Excellence for Environmental Decisions, Australian Research Council
• WT
  Wellcome Trust
• NI
  National Institute for Health and Care Research
• EC
  European Commission
• MR
  Medical Research Council

  Award: MR/K005707/1
• NE
  NIHR Exeter Clinical Research Facility