Genetic Variant BDNF (Val66Met) Polymorphism Alters Anxiety-Related Behavior
Shandong University · Cornell University · +1 more institution
Abstract
A common single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is associated with alterations in brain anatomy and memory, but its relevance to clinical disorders is unclear. We generated a variant BDNF mouse (BDNF(Met/Met)) that reproduces the phenotypic hallmarks in humans with the variant allele. BDNF(Met) was expressed in brain at normal levels, but its secretion from neurons was defective. When placed in stressful settings, BDNF(Met/Met) mice exhibited increased anxiety-related behaviors that were not normalized by the antidepressant, fluoxetine. A variant BDNF may thus play a key role in genetic…
Citation impact
- FWCI
- 20.66
- Percentile
- 100%
- References
- 28
Authors
12- ZCZhe-Yu ChenCorresponding
Shandong University, Cornell University, Rockefeller University
- DJDeqiang JingCorresponding
Shandong University, Cornell University, Rockefeller University
- KGKevin G. BathCorresponding
Shandong University, Cornell University, Rockefeller University
- AIAlessandro Ieraci
Shandong University, Cornell University, Rockefeller University
- TKTanvir Khan
Shandong University, Cornell University, Rockefeller University
Topics & keywords
- Neurotrophic factors
- Brain-derived neurotrophic factor
- rs6265
- Anxiety
- Allele
- Psychology
- Antidepressant
- Tropomyosin receptor kinase B
- Good health and well-being