Characterization of the piRNA Complex from Rat Testes
Massachusetts General Hospital · Harvard–MIT Division of Health Sciences and Technology · +3 more institutions
Abstract
Small noncoding RNAs regulate processes essential for cell growth and development, including mRNA degradation, translational repression, and transcriptional gene silencing (TGS). During a search for candidate mammalian factors for TGS, we purified a complex that contains small RNAs and Riwi, the rat homolog to human Piwi. The RNAs, frequently 29 to 30 nucleotides in length, are called Piwi-interacting RNAs (piRNAs), 94% of which map to 100 defined (
Citation impact
- FWCI
- 92.77
- Percentile
- 100%
- References
- 26
Authors
7- NCNelson C. LauCorresponding
Massachusetts General Hospital, Harvard–MIT Division of Health Sciences and Technology, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, The University of Osaka
- AGAnita G. Seto
Massachusetts General Hospital, Harvard–MIT Division of Health Sciences and Technology, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, The University of Osaka
- JKJin‐Kuk Kim
Massachusetts General Hospital, Harvard–MIT Division of Health Sciences and Technology, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, The University of Osaka
- SKSatomi Kuramochi‐Miyagawa
Massachusetts General Hospital, Harvard–MIT Division of Health Sciences and Technology, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, The University of Osaka
- TNToru Nakano
Massachusetts General Hospital, Harvard–MIT Division of Health Sciences and Technology, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, The University of Osaka
Topics & keywords
- Piwi-interacting RNA
- Gene silencing
- Biology
- Gene
- Small nucleolar RNA
- Genetics
- Psychological repression
- RasiRNA