Generation of Gut-Homing IgA-Secreting B Cells by Intestinal Dendritic Cells
Boston Biomedical Research Institute · Immune Regulation (United Kingdom) · +3 more institutions
Abstract
Normal intestinal mucosa contains abundant immunoglobulin A (IgA)-secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic cells (DC) from GALT induce T cell-independent expression of IgA and gut-homing receptors on B cells. GALT-DC-derived retinoic acid (RA) alone conferred gut tropism but could not promote IgA secretion. However, RA potently synergized with GALT-DC-derived interleukin-6 (IL-6) or IL-5 to induce IgA secretion. Consequently, mice deficient in the RA precursor vitamin A lacked IgA-secreting cells in the small intestine. Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effector activity through synergistically…
Citation impact
- FWCI
- 20.67
- Percentile
- 100%
- References
- 30
Authors
13- JRJ. Rodrigo MoraCorresponding
Boston Biomedical Research Institute, Immune Regulation (United Kingdom), University of Milano-Bicocca, University of Birmingham, Tokushima Bunri University
- MIMakoto IwataCorresponding
Boston Biomedical Research Institute, Immune Regulation (United Kingdom), University of Milano-Bicocca, University of Birmingham, Tokushima Bunri University
- BEBertus EksteenCorresponding
Boston Biomedical Research Institute, Immune Regulation (United Kingdom), University of Milano-Bicocca, University of Birmingham, Tokushima Bunri University
- SSSi‐Young Song
Boston Biomedical Research Institute, Immune Regulation (United Kingdom), University of Milano-Bicocca, University of Birmingham, Tokushima Bunri University
- TJTobias Junt
Boston Biomedical Research Institute, Immune Regulation (United Kingdom), University of Milano-Bicocca, University of Birmingham, Tokushima Bunri University
Topics & keywords
- Gut-associated lymphoid tissue
- Secretion
- Biology
- Homing (biology)
- Immunoglobulin A
- Microfold cell
- Immunology
- Dendritic cell