IL-1 is required for tumor invasiveness and angiogenesis
Ben-Gurion University of the Negev · University of Colorado Health · +2 more institutions
Abstract
Here, we describe that microenvironmental IL-1 beta and, to a lesser extent, IL-1 alpha are required for in vivo angiogenesis and invasiveness of different tumor cells. In IL-1 beta knockout (KO) mice, local tumor or lung metastases of B16 melanoma cells were not observed compared with WT mice. Angiogenesis was assessed by the recruitment of blood vessel networks into Matrigel plugs containing B16 melanoma cells; vascularization of the plugs was present in WT mice, but was absent in IL-1 beta KO mice. The addition of exogenous IL-1 into B16-containing Matrigel plugs in IL-1 beta KO mice partially restored the angiogenic response. Moreover, the incorporation of IL-1 receptor antagonist to B16-containing plugs…
Citation impact
- FWCI
- 11.80
- Percentile
- 100%
- References
- 52
Authors
8- EVElena VoronovCorresponding
Ben-Gurion University of the Negev, University of Colorado Health, Cancer Research Center, The University of Tokyo
- DSDror S. Shouval
Ben-Gurion University of the Negev, University of Colorado Health, Cancer Research Center, The University of Tokyo
- YKYakov Krelin
Ben-Gurion University of the Negev, University of Colorado Health, Cancer Research Center, The University of Tokyo
- ECEmanuela Cagnano
Ben-Gurion University of the Negev, University of Colorado Health, Cancer Research Center, The University of Tokyo
- DBDaniel Benharroch
Ben-Gurion University of the Negev, University of Colorado Health, Cancer Research Center, The University of Tokyo
Topics & keywords
- Matrigel
- Angiogenesis
- In vivo
- Biology
- Neovascularization
- Cancer research
- Melanoma
- Cytokine
- Good health and well-being