The inflammatory response in myocardial infarction
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Abstract
One of the major therapeutic goals of modern cardiology is to design strategies aimed at minimizing myocardial necrosis and optimizing cardiac repair following myocardial infarction. However, a sound understanding of the biology is necessary before a specific intervention is pursued on a therapeutic basis. This review summarizes our current understanding of the cellular and molecular mechanisms regulating the inflammatory response following myocardial ischemia and reperfusion. Myocardial necrosis induces complement activation and free radical generation, triggering a cytokine cascade initiated by Tumor Necrosis Factor (TNF)-alpha release. If reperfusion of the infarcted area is initiated, it is attended by an…
Citation impact
1,988
total citations
- FWCI
- 44.85
- Percentile
- 100%
- References
- 182
Citations per year
Authors
1Topics & keywords
Topics
Keywords
- Medicine
- Tumor necrosis factor alpha
- Monocyte
- Inflammation
- Cytokine
- Immunology
- Selectin
- Integrin
UN Sustainable Development Goals
- Good health and well-being
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