The African Genome Variation Project shapes medical genetics in Africa

Given the importance of Africa to studies of human origins and disease susceptibility, detailed characterization of African genetic diversity is needed. The African Genome Variation Project provides a resource with which to design, implement and interpret genomic studies in sub-Saharan Africa and worldwide. The African Genome Variation Project represents dense genotypes from 1,481 individuals and whole-genome sequences from 320 individuals across sub-Saharan Africa. Using this resource, we find novel evidence of complex, regionally distinct hunter-gatherer and Eurasian admixture across sub-Saharan Africa. We identify new loci under selection, including loci related to malaria susceptibility and hypertension.…

• FF
  Foundation for the National Institutes of Health
• BA
  Bill and Melinda Gates Foundation
• WT
  Wellcome Trust

  Award: WT098051
• S
  Servier
• VD
  Victor Daitz Foundation
• NI
  National Institutes of Health
• MR
  Medical Research Council

  Award: MR/K013491/1
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases
• NI
  National Institute on Minority Health and Health Disparities