Myocardial ischemia-reperfusion injury: a neglected therapeutic target

Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is timely and effective myocardial reperfusion using either thombolytic therapy or primary percutaneous coronary intervention (PPCI). However, the process of reperfusion can itself induce cardiomyocyte death, known as myocardial reperfusion injury, for which there is still no effective therapy. A number of new therapeutic strategies currently under investigation for preventing myocardial reperfusion injury have the potential to improve clinical outcomes in patients with acute MI treated with PPCI.

• NI
  National Institute for Health and Care Research
• BH
  British Heart Foundation

  Awards: RG/03/007, FS/06/023
• UC
  University College London
• MR
  Medical Research Council

  Award: MR/K002066/1