reviewThe Journal of Clinical Endocrinology & MetabolismNov 1, 2008BRONZE OA

Adipocytokines and the Metabolic Complications of Obesity

NRNeda RasouliPAPhilip A. Kern

Central Arkansas Veterans Healthcare System · University of Arkansas for Medical Sciences

PubMed
Indexed incrossrefpubmed

Abstract

CONTEXT: Adipose tissue is increasingly recognized as an active endocrine organ with many secretory products and part of the innate immune system. With obesity, macrophages infiltrate adipose tissue, and numerous adipocytokines are released by both macrophages and adipocytes. Adipocytokines play important roles in the pathogenesis of insulin resistance and associated metabolic complications such as dyslipidemia, hypertension, and premature heart disease. EVIDENCE ACQUISITION: Published literature was analyzed with the intent of addressing the role of the major adipose secretory proteins in human obesity, insulin resistance, and type 2 diabetes. EVIDENCE SYNTHESIS: This review analyzes the characteristics of…

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742
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FWCI
43.16
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100%
References
161
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Authors

2

Topics & keywords

Topics
Keywords
  • Adipokine
  • Insulin resistance
  • Adipose tissue
  • Resistin
  • Adiponectin
  • Retinol binding protein 4
  • Endocrinology
  • Medicine
UN Sustainable Development Goals
  • Good health and well-being
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