articleJournal of Agricultural and Food ChemistryDec 16, 2004Closed access

Interaction of Flavonoids with Bovine Serum Albumin:  A Fluorescence Quenching Study

APAthina PapadopoulouRJRebecca J. GreenRARichard A. Frazier

University of Reading

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Abstract

The interaction between four flavonoids (catechin, epicatechin, rutin, and quercetin) and bovine serum albumin (BSA) was investigated using tryptophan fluorescence quenching. Quenching constants were determined using the Stern-Volmer equation to provide a measure of the binding affinity between the flavonoids and BSA. The binding affinity was strongest for quercetin and ranked in the order quercetin > rutin > epicatechin = catechin. The pH in the range of 5-7.4 does not affect significantly (p

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Topics & keywords

Topics
Keywords
  • Rutin
  • Quercetin
  • Chemistry
  • Tryptophan
  • Quenching (fluorescence)
  • Catechin
  • Bovine serum albumin
  • Flavonoid
UN Sustainable Development Goals
  • Clean water and sanitation
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