Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

Tacke, Frank; Álvarez, David; Kaplan, Theodore; Jakubzick, Claudia; Spanbroek, Rainer; Llodrá, Jaime; Garin, Alexandre; Liu, Jianhua; Mack, Matthias; Rooijen, Nico van; Lira, Sérgio A.; Habenicht, Andreas J. R.; Randolph, Gwendalyn J.

doi:10.1172/jci28549

articleJournal of Clinical InvestigationJan 2, 2007BRONZE OA

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

FTFrank Tacke DÁDavid Álvarez TKTheodore Kaplan CJClaudia Jakubzick RSRainer Spanbroek

Icahn School of Medicine at Mount Sinai · Miller Orthopedic Specialist · +1 more institution

PubMed

Indexed incrossrefdoajpubmed

Abstract

Monocytes participate critically in atherosclerosis. There are 2 major subsets expressing different chemokine receptor patterns: CCR2(+)CX3CR1(+)Ly-6C(hi) and CCR2(-)CX3CR1(++)Ly-6C(lo) monocytes. Both C-C motif chemokine receptor 2 (CCR2) and C-X(3)-C motif chemokine receptor 1 (CX3CR1) are linked to progression of atherosclerotic plaques. Here, we analyzed mouse monocyte subsets in apoE-deficient mice and traced their differentiation and chemokine receptor usage as they accumulated within atherosclerotic plaques. Blood monocyte counts were elevated in apoE(-/-) mice and skewed toward an increased frequency of CCR2(+)Ly-6C(hi) monocytes in apoE(-/-) mice fed a high-fat diet. CCR2(+)Ly-6C(hi) monocytes…

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Topics

Keywords

CCR2
CX3CR1
Monocyte
Chemokine receptor
Chemokine
CC chemokine receptors
Immunology
CD11c

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