One Juliet and four Romeos: VeA and its methyltransferases
National University of Ireland, Maynooth · Northern Research Station · +2 more institutions
Abstract
Fungal secondary metabolism has become an important research topic with great biomedical and biotechnological value. In the postgenomic era, understanding the diversity and the molecular control of secondary metabolites (SMs) are two challenging tasks addressed by the research community. Discovery of the LaeA methyltransferase 10 years ago opened up a new horizon on the control of SM research when it was found that expression of many SM gene clusters is controlled by LaeA. While the molecular function of LaeA remains an enigma, discovery of the velvet family proteins as interaction partners further extended the role of the LaeA beyond secondary metabolism. The heterotrimeric VelB-VeA-LaeA complex plays…
Citation impact
- FWCI
- 126.02
- Percentile
- 100%
- References
- 48
Authors
5- ÃSÖzlem Sarikaya-BayramCorresponding
National University of Ireland, Maynooth
- JPJonathan Palmer
Northern Research Station
- NPNancy P. Keller
University of Wisconsin–Madison
- GHGerhard H. Braus
University of Göttingen
- ÃBÖzgür Bayram
National University of Ireland, Maynooth
Topics & keywords
- Methyltransferase
- Secondary metabolism
- Function (biology)
- Secondary metabolite
- Biology
- Heterotrimeric G protein
- Genetics
- Computational biology