articleACS NanoDec 4, 2013Closed access

Curcumin-Loaded Nanoparticles Potently Induce Adult Neurogenesis and Reverse Cognitive Deficits in Alzheimer’s Disease Model via Canonical Wnt/β-Catenin Pathway

SKShashi Kant TiwariSASwati AgarwalBSBrashket SethAYAnuradha YadavSNSaumya Nair

Indian Institute of Toxicology Research · Academy of Scientific and Innovative Research · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Neurogenesis, a process of generation of new neurons, is reported to be reduced in several neurodegenerative disorders including Alzheimer's disease (AD). Induction of neurogenesis by targeting endogenous neural stem cells (NSC) could be a promising therapeutic approach to such diseases by influencing the brain self-regenerative capacity. Curcumin, a neuroprotective agent, has poor brain bioavailability. Herein, we report that curcumin-encapsulated PLGA nanoparticles (Cur-PLGA-NPs) potently induce NSC proliferation and neuronal differentiation in vitro and in the hippocampus and subventricular zone of adult rats, as compared to uncoated bulk curcumin. Cur-PLGA-NPs induce neurogenesis by internalization into…

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553
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16

Topics & keywords

Topics
Keywords
  • Neurogenesis
  • Curcumin
  • Neural stem cell
  • Wnt signaling pathway
  • AXIN2
  • Subventricular zone
  • Cell biology
  • Neuroinflammation
UN Sustainable Development Goals
  • Good health and well-being
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