H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
Johns Hopkins University · Johns Hopkins Medicine · +2 more institutions
Abstract
Studies of nitric oxide over the past two decades have highlighted the fundamental importance of gaseous signaling molecules in biology and medicine. The physiological role of other gases such as carbon monoxide and hydrogen sulfide (H2S) is now receiving increasing attention. Here we show that H2S is physiologically generated by cystathionine gamma-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H2S levels in the serum, heart, aorta, and other tissues. Mutant mice lacking CSE display pronounced hypertension and diminished endothelium-dependent vasorelaxation. CSE is physiologically activated by calcium-calmodulin, which is a mechanism for H2S formation in response to vascular…
Citation impact
- FWCI
- 60.99
- Percentile
- 100%
- References
- 27
Authors
12- GYGuangdong Yang
Johns Hopkins University, Johns Hopkins Medicine, University of Saskatchewan, Lakehead University
- LWLingyun WuCorresponding
Johns Hopkins University, Johns Hopkins Medicine, University of Saskatchewan, Lakehead University
- BJBo Jiang
Johns Hopkins University, Johns Hopkins Medicine, University of Saskatchewan, Lakehead University
- WYWei Yang
Johns Hopkins University, Johns Hopkins Medicine, University of Saskatchewan, Lakehead University
- JQJiansong Qi
Johns Hopkins University, Johns Hopkins Medicine, University of Saskatchewan, Lakehead University
Topics & keywords
- Cystathionine beta synthase
- Cystathionine gamma-lyase
- Nitric oxide
- Hydrogen sulfide
- Vasodilation
- Chemistry
- Mutant
- Calcium
- Clean water and sanitation