A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells

Fogg, Darin K.; Sibon, Claire; Miled, Chaouki; Jung, Steffen; Aucouturier, Pièrre; Littman, Dan R.; Cumano, Ana; Geissmann, Frédéric

doi:10.1126/science.1117729

articleScienceDec 1, 2005Closed access

A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells

DKDarin K. Fogg CSClaire Sibon CMChaouki Miled SJSteffen Jung PAPièrre Aucouturier

Howard Hughes Medical Institute · Inserm · +5 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Macrophages and dendritic cells (DCs) are crucial for immune and inflammatory responses and belong to a network of cells that has been termed the mononuclear phagocyte system (MPS). However, the origin and lineage of these cells remain poorly understood. Here, we describe the isolation and clonal analysis of a mouse bone marrow progenitor that is specific for monocytes, several macrophage subsets, and resident spleen DCs in vivo. It was also possible to recapitulate this differentiation in vitro by using treatment with the cytokines macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. Thus, macrophages and DCs appear to renew from a common progenitor, providing a cellular…

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Topics & keywords

Topics

Keywords

Bone marrow
Progenitor cell
Macrophage
Mononuclear phagocyte system
Biology
Immunology
Follicular dendritic cells
Colony-stimulating factor

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