articleJournal of the American Chemical SocietyMar 12, 2010HYBRID OA

Gold Nanoparticles for the Improved Anticancer Drug Delivery of the Active Component of Oxaliplatin

SDSarah D. BrownPNPaola NativoJSJ.L. SmithDSDavid StirlingPRP. R. Edwards

University of Strathclyde · Cancer Research UK

PubMed
Indexed incrossrefpubmed

Abstract

The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important component of chemotherapy but are limited by severe dose-limiting side effects and the ability of tumors to develop resistance rapidly. These drugs can be improved through the use of drug-delivery vehicles that are able to target cancers passively or actively. In this study, we have tethered the active component of the anticancer drug oxaliplatin to a gold nanoparticle for improved drug delivery. Naked gold nanoparticles were functionalized with a thiolated poly(ethylene glycol) (PEG) monolayer capped with a carboxylate group. [Pt(1R,2R-diaminocyclohexane)(H(2)O)(2)]2NO(3) was added to the PEG surface to yield a…

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854
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Authors

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Topics & keywords

Topics
Keywords
  • Oxaliplatin
  • Chemistry
  • Cisplatin
  • Cytotoxicity
  • Carboplatin
  • Ethylene glycol
  • Drug delivery
  • Drug
UN Sustainable Development Goals
  • Good health and well-being
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