Identification of metastasis-related microRNAs in hepatocellular carcinoma
Genesis Foundation · National Cancer Institute · +5 more institutions
Abstract
MicroRNAs (miRNAs) have been used as cancer-related biomarkers. Hepatocellular carcinoma (HCC) is an aggressive cancer with a dismal outcome largely due to metastasis and postsurgical recurrence. We investigated whether the expression of certain miRNAs are associated with HCC metastasis. We examined the miRNA expression profiles of 482 cancerous and noncancerous specimens from radical resection of 241 patients with HCC. Using a supervised algorithm and a clinically well-defined cohort of 131 cases, we built a unique 20-miRNA metastasis signature that could significantly predict (P
Citation impact
- FWCI
- 21.28
- Percentile
- 100%
- References
- 53
Authors
12- ABAnuradha Budhu
Genesis Foundation, National Cancer Institute, Center for Cancer Research
- HJHu‐Liang Jia
Fudan University, Genesis Foundation, Zhongshan Hospital, National Cancer Institute, Center for Cancer Research
- MFMarshonna Forgues
Genesis Foundation, National Cancer Institute, Center for Cancer Research
- CLChang–Gong Liu
The Ohio State University
- DGD. Goldstein
Office of Science, National Cancer Institute, Center for Cancer Research
Topics & keywords
- Hepatocellular carcinoma
- Identification (biology)
- Metastasis
- microRNA
- Medicine
- Oncology
- Cancer research
- Computational biology
- Good health and well-being