Global signatures of protein and mRNA expression levels
The University of Texas at San Antonio Health Science Center · Children's Cancer Center · +1 more institution
Abstract
Cellular states are determined by differential expression of the cell's proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contributors to gene expression regulation. This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters. We summarize the information that can be derived from comparison of protein and mRNA expression levels and discuss how corresponding sequence characteristics suggest modes of regulation.
Citation impact
- FWCI
- 13.00
- Percentile
- 100%
- References
- 190
Authors
4- RDRaquel de Sousa Abreu
The University of Texas at San Antonio Health Science Center, Children's Cancer Center
- LOLuiz O. F. Penalva
The University of Texas at San Antonio Health Science Center, Children's Cancer Center
- EMEdward M. Marcotte
The University of Texas at Austin
- CVChristine VogelCorresponding
The University of Texas at Austin
Topics & keywords
- Messenger RNA
- Gene expression
- Biology
- Protein expression
- Protein stability
- Translation (biology)
- Cell biology
- Transcription (linguistics)