Impact of Obesity on Plasma Natriuretic Peptide Levels
Harvard University · Massachusetts General Hospital · +2 more institutions
Abstract
BACKGROUND: The mechanisms linking obesity to hypertension have not been established, but sodium retention and excessive sympathetic tone are key contributors. The natriuretic peptides are important regulators of sodium homeostasis and neurohormonal activation, raising the possibility that obese individuals have an impaired natriuretic peptide response. METHODS AND RESULTS: We examined the relations of plasma B-type natriuretic peptide (BNP) and N-terminal proatrial natriuretic peptide (N-ANP) to body mass index in 3389 Framingham Study participants (1803 women) without heart failure. Multivariable regression analyses were performed, adjusting for clinical and echocardiographic covariates. BNP levels below the…
Citation impact
- FWCI
- 30.18
- Percentile
- 100%
- References
- 36
Authors
7- TJThomas J. WangCorresponding
Harvard University, Massachusetts General Hospital, National Heart Lung and Blood Institute, Framingham Heart Study
- MGMartin G. Larson
Harvard University, Massachusetts General Hospital, National Heart Lung and Blood Institute, Framingham Heart Study
- DLDaniel Levy
Harvard University, Massachusetts General Hospital, National Heart Lung and Blood Institute, Framingham Heart Study
- EJEmelia J. Benjamin
Harvard University, Massachusetts General Hospital, National Heart Lung and Blood Institute, Framingham Heart Study
- ELEric Leip
Harvard University, Massachusetts General Hospital, National Heart Lung and Blood Institute, Framingham Heart Study
Topics & keywords
- Medicine
- Internal medicine
- Natriuretic peptide
- Endocrinology
- Odds ratio
- Overweight
- Body mass index
- Atrial natriuretic peptide
- Good health and well-being