IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy
Centre National de la Recherche Scientifique · Institut de Pharmacologie et de Biologie Structurale · +2 more institutions
Abstract
IL-33 is a nuclear cytokine from the IL-1 family constitutively expressed in epithelial barrier tissues and lymphoid organs, which plays important roles in type-2 innate immunity and human asthma. Recent studies indicate that IL-33 induces production of large amounts of IL-5 and IL-13 by group 2 innate lymphoid cells (ILC2s), for initiation of allergic inflammation shortly after exposure to allergens or infection with parasites or viruses. IL-33 appears to function as an alarmin (alarm signal) rapidly released from producing cells upon cellular damage or cellular stress. In this review, we discuss the cellular sources, mode of action and regulation of IL-33, and we highlight its crucial roles in vivo with…
Citation impact
- FWCI
- 22.88
- Percentile
- 100%
- References
- 50
Authors
2- CCCorinne Cayrol
Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Université Fédérale de Toulouse Midi-Pyrénées, Université Toulouse III - Paul Sabatier
- JGJean‐Philippe GirardCorresponding
Université Fédérale de Toulouse Midi-Pyrénées, Université Toulouse III - Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique
Topics & keywords
- Innate lymphoid cell
- Immunology
- Interleukin 33
- Inflammation
- Innate immune system
- Cytokine
- Biology
- Allergic inflammation
- Good health and well-being