Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
Thomas Jefferson University · Sidney Kimmel Cancer Center · +1 more institution
Abstract
We provide a comprehensive classification of the proteoglycan gene families and respective protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores. These three signatures were utilized to design four major classes of proteoglycans with distinct forms and functions: the intracellular, cell-surface, pericellular and extracellular proteoglycans. The proposed nomenclature encompasses forty-three distinct proteoglycan-encoding genes and many alternatively-spliced variants. The biological functions of these four proteoglycan families are critically…
Citation impact
- FWCI
- 43.64
- Percentile
- 100%
- References
- 649
Authors
2Topics & keywords
- Proteoglycan
- Nomenclature
- Biology
- Gene
- Intracellular
- Extracellular matrix
- Computational biology
- Function (biology)