articleThe Journal of Experimental MedicineApr 12, 2010BRONZE OA

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

ICIrving C. AllenEMErin McElvaniaRTRita-Marie T. WoodfordJMJoshua M. UronisEKEda K. Holl

University of North Carolina at Chapel Hill · Center for Digestive and Liver Diseases · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Colitis-associated cancer (CAC) is a major complication of inflammatory bowel diseases. We show that components of the inflammasome are protective during acute and recurring colitis and CAC in the dextran sulfate sodium (DSS) and azoxymethane + DSS models. Mice lacking the inflammasome adaptor protein PYCARD (ASC) and caspase-1 demonstrate increased disease outcome, morbidity, histopathology, and polyp formation. The increased tumor burden is correlated with attenuated levels of IL-1beta and IL-18 at the tumor site. To decipher the nucleotide-binding domain, leucine-rich-repeat-containing (NLR) component that is involved in colitis and CAC, we assessed Nlrp3 and Nlrc4 deficient mice. Nlrp3(-/-) mice showed an…

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817
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23.41
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100%
References
45
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Authors

9

Topics & keywords

Topics
Keywords
  • Inflammasome
  • Azoxymethane
  • Colitis
  • NLRC4
  • Inflammatory bowel disease
  • Immunology
  • Cancer research
  • Colorectal cancer
UN Sustainable Development Goals
  • Good health and well-being
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