High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions
Inserm · Génomique Fonctionnelle des Tumeurs Solides · +11 more institutions
Abstract
Somatic mutations activating telomerase reverse-trancriptase promoter were recently identified in several tumour types. Here we identify frequent similar mutations in human hepatocellular carcinomas (59%), cirrhotic preneoplastic macronodules (25%) and hepatocellular adenomas with malignant transformation in hepatocellular carcinomas (44%). In hepatocellular tumours, telomerase reverse-transcripase- and CTNNB1-activating mutations are significantly associated. Moreover, preliminary data suggest that telomerase reverse-trancriptase promoter mutations can increase the expression of telomerase transcript. In conclusion, telomerase reverse-trancriptase promoter mutation is the earliest recurrent genetic event…
Citation impact
- FWCI
- 27.37
- Percentile
- 100%
- References
- 34
Authors
10- JNJean‐Charles NaultCorresponding
Inserm, Génomique Fonctionnelle des Tumeurs Solides
- MMMaxime Mallet
Délégation Paris 5, Inserm, Université Paris Cité, Sorbonne Paris Cité, Génomique Fonctionnelle des Tumeurs Solides
- CPCamilla Pilati
Délégation Paris 5, Inserm, Université Paris Cité, Sorbonne Paris Cité, Génomique Fonctionnelle des Tumeurs Solides
- JCJulien Caldéraro
Délégation Paris 5, Inserm, Université Paris Cité, Centre Hospitalier Universitaire Henri-Mondor, Sorbonne Paris Cité, Hôpitaux Universitaires Henri-Mondor, Génomique Fonctionnelle des Tumeurs Solides
- PBPaulette Bioulac‐Sage
Inserm, Hôpital Pellegrin
Topics & keywords
- Telomerase
- Hepatocellular carcinoma
- Telomerase reverse transcriptase
- Somatic cell
- Reverse transcriptase
- Cancer research
- Malignant transformation
- Mutation
- Good health and well-being