The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults

Several previous reports of small cohorts have found significantly higher serum 1,25-dihydroxy vitamin D (1,25-vit D) in obese compared with nonobese whites. Based on these reports and on recent in vitro studies of adipocytes which suggest that administration of 1,25-vit D can stimulate lipogenesis and inhibit lipolysis, some investigators have proposed that high 1,25-vit D may play a role in promoting or maintaining adipocyte triglyceride stores in obese adults. To test the hypothesis that obesity is commonly associated with increased 1,25-vit D, we examined the relationships between calciotropic hormones and body adiposity in a large cohort of healthy adults. Serum intact PTH, 25-hydroxy vitamin D, and…

• UD
  U.S. Department of Health and Human Services
• OO
  Office of Dietary Supplements
• G
  GlaxoSmithKline
• NI
  National Institutes of Health

  Award: ZO1 HD-00641
• UP
  U.S. Public Health Service
• NI
  National Institute of Child Health and Human Development

  Award: ZO1 HD-00641