Breast cancer stem cells, cytokine networks, and the tumor microenvironment

Many tumors, including breast cancer, are maintained by a subpopulation of cells that display stem cell properties, mediate metastasis, and contribute to treatment resistance. These cancer stem cells (CSCs) are regulated by complex interactions with the components of the tumor microenvironment - including mesenchymal stem cells, adipocytes, tumor associated fibroblasts, endothelial cells, and immune cells - through networks of cytokines and growth factors. Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development.

• AA
  American Association for Cancer Research
• BC
  Breast Cancer Research Foundation
• UO
  University of Michigan

  Award: 48109
• NI
  National Institutes of Health

  Award: CA101860
• CO
  College of Pharmacy, University of Michigan
• SU
  Stand Up To Cancer
• CC
  Comprehensive Cancer Center, University of Michigan