The Intestinal Microbiome in Early Life: Health and Disease
Canada's Michael Smith Genome Sciences Centre · University of British Columbia · +1 more institution
Abstract
Human microbial colonization begins at birth and continues to develop and modulate in species abundance for about 3 years, until the microbiota becomes adult-like. During the same time period, children experience significant developmental changes that influence their health status as well as their immune system. An ever-expanding number of articles associate several diseases with early-life imbalances of the gut microbiota, also referred to as gut microbial dysbiosis. Whether early-life dysbiosis precedes and plays a role in disease pathogenesis, or simply originates from the disease process itself is a question that is beginning to be answered in a few diseases, including IBD, obesity, and asthma. This review…
Citation impact
- FWCI
- 29.59
- Percentile
- 100%
- References
- 256
Authors
5- MAMarie‐Claire Arrieta
Canada's Michael Smith Genome Sciences Centre, University of British Columbia
- LTLeah T. Stiemsma
Child and Family Research Institute, University of British Columbia
- NANelly Amenyogbe
University of British Columbia, Child and Family Research Institute
- EBEric Brown
University of British Columbia, Canada's Michael Smith Genome Sciences Centre
- BBB. Brett FinlayCorresponding
Canada's Michael Smith Genome Sciences Centre, University of British Columbia
Topics & keywords
- Dysbiosis
- Microbiome
- Disease
- Gut flora
- Immune system
- Immunology
- Biology
- Medicine