Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

We provide a demonstration in humans of the principle of pharmacometabonomics by showing a clear connection between an individual's metabolic phenotype, in the form of a predose urinary metabolite profile, and the metabolic fate of a standard dose of the widely used analgesic acetaminophen. Predose and postdose urinary metabolite profiles were determined by (1)H NMR spectroscopy. The predose spectra were statistically analyzed in relation to drug metabolite excretion to detect predose biomarkers of drug fate and a human-gut microbiome cometabolite predictor was identified. Thus, we found that individuals having high predose urinary levels of p-cresol sulfate had low postdose urinary ratios of acetaminophen…

• P
  Pfizer
• IC
  Imperial College London
• KC
  King's College London
• WU
  Wuhan University
• MR
  Medical Research Council
• RH
  Royal Holloway, University of London