Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression
Centre National de la Recherche Scientifique · University of Lisbon · +6 more institutions
Abstract
During progression from single cancer cells to a tumor mass and metastases, tumor cells send signals that can subvert their tissue microenvironment. These signals involve soluble molecules and various extracellular vesicles, including a particular type termed exosomes. The specific roles of exosomes secreted in the tumor microenvironment, however, is unclear. The small GTPases RAB27A and RAB27B regulate exocytosis of multivesicular endosomes, which lead to exosome secretion, in human HeLa cells. Here, we used mouse models to show that Rab27a blockade in mammary carcinoma cells decreased secretion of exosomes characterized by endocytic markers, but also of matrix metalloproteinase 9, which is not associated…
Citation impact
- FWCI
- 15.85
- Percentile
- 100%
- References
- 53
Authors
8- ABAngélique BobrieCorresponding
Centre National de la Recherche Scientifique, University of Lisbon, Inserm, Université Paris Cité, Biologie cellulaire et Cancer, Imperial College London, Institut Curie, Universidade Nova de Lisboa
- SKSophie Krumeich
Centre National de la Recherche Scientifique, University of Lisbon, Inserm, Université Paris Cité, Biologie cellulaire et Cancer, Imperial College London, Institut Curie, Universidade Nova de Lisboa
- FRFabien Reyal
Centre National de la Recherche Scientifique, University of Lisbon, Inserm, Université Paris Cité, Biologie cellulaire et Cancer, Imperial College London, Institut Curie, Universidade Nova de Lisboa
- CRChiara Recchi
Centre National de la Recherche Scientifique, University of Lisbon, Inserm, Université Paris Cité, Biologie cellulaire et Cancer, Imperial College London, Institut Curie, Universidade Nova de Lisboa
- LFLuís F. Moita
Centre National de la Recherche Scientifique, University of Lisbon, Inserm, Université Paris Cité, Biologie cellulaire et Cancer, Imperial College London, Institut Curie, Universidade Nova de Lisboa
Topics & keywords
- Microvesicles
- Tumor microenvironment
- Exosome
- Tumor progression
- Secretion
- Cancer research
- Cell biology
- Biology
- Good health and well-being