Understanding the effect of mean pore size on cell activity in collagen-glycosaminoglycan scaffolds
Royal College of Surgeons in Ireland · Trinity College Dublin
Abstract
Mean pore size is an essential aspect of scaffolds for tissue-engineering. If pores are too small cells cannot migrate in towards the center of the construct limiting the diffusion of nutrients and removal of waste products. Conversely, if pores are too large there is a decrease in specific surface area available limiting cell attachment. However the relationship between scaffold pore size and cell activity is poorly understood and as a result there are conflicting reports within the literature on the optimal pore size required for successful tissue-engineering. Previous studies in bone tissue-engineering have indicated a range of mean pore sizes (96–150 µm) to facilitate optimal attachment. Other studies have…
Citation impact
- FWCI
- 7.17
- Percentile
- 100%
- References
- 25
Authors
2Topics & keywords
- Limiting
- Tissue engineering
- Scaffold
- Chemistry
- Materials science
- Glycosaminoglycan
- Biophysics
- Biomedical engineering
- Clean water and sanitation