Cellular mechanotransduction: putting all the pieces together again

Analysis of cellular mechanotransduction, the mechanism by which cells convert mechanical signals into biochemical responses, has focused on identification of critical mechanosensitive molecules and cellular components. Stretch-activated ion channels, caveolae, integrins, cadherins, growth factor receptors, myosin motors, cytoskeletal filaments, nuclei, extracellular matrix, and numerous other structures and signaling molecules have all been shown to contribute to the mechanotransduction response. However, little is known about how these different molecules function within the structural context of living cells, tissues, and organs to produce the orchestrated cellular behaviors required for mechanosensation,…

• UD
  U.S. Department of Defense
• NA
  National Aeronautics and Space Administration
• NI
  National Institutes of Health
• DA
  Defense Advanced Research Projects Agency