reviewProceedings of the National Academy of SciencesMar 28, 2006GREEN OA

Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease

RWRobert W. MahleyKHKarl H. WeisgraberYHYadong Huang

Gladstone Institutes · University of California, San Francisco · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

The premise of this review is that apolipoprotein (apo) E4 is much more than a contributing factor to neurodegeneration. ApoE has critical functions in redistributing lipids among CNS cells for normal lipid homeostasis, repairing injured neurons, maintaining synapto-dendritic connections, and scavenging toxins. In multiple pathways affecting neuropathology, including Alzheimer's disease, apoE acts directly or in concert with age, head injury, oxidative stress, ischemia, inflammation, and excess amyloid beta peptide production to cause neurological disorders, accelerating progression, altering prognosis, or lowering age of onset. We envision that unique structural features of apoE4 are responsible for…

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911
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Authors

3

Topics & keywords

Topics
Keywords
  • Neuropathology
  • Neurodegeneration
  • Apolipoprotein E
  • Biology
  • Cell biology
  • Alzheimer's disease
  • Neuroscience
  • Proteolysis
UN Sustainable Development Goals
  • Affordable and clean energy
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