Chromosomal Instability and Tumors Promoted by DNA Hypomethylation
Massachusetts Institute of Technology · Whitehead Institute for Biomedical Research
Indexed incrossrefpubmed
Abstract
Human tumors often display changes in DNA methylation, including both genome-wide hypomethylation and site-specific hypermethylation ( [1][1], [2][2] ). In mice, DNA hypomethylation is sufficient to induce T cell lymphomas with consistent gain of chromosome 15 ( [3][3] ), indicating that genome-wide
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Authors
4- AEAmir Eden
Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research
- FGFrançois Gaudet
Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research
- AWAlpana Waghmare
Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research
- RJRudolf JaenischCorresponding
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
Topics & keywords
Topics
Keywords
- Chromosome instability
- Genome instability
- DNA
- DNA methylation
- Instability
- Biology
- Microsatellite instability
- Genetics
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