Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China

UNLABELLED: Genetic factors, as well as environmental factors, play a role in development of nasopharyngeal carcinoma (NPC). A number of single nucleotide polymorphisms (SNPs) have been reported to be associated with NPC. To confirm these genetic associations with NPC, two independent case-control studies from Southern China comprising 1166 NPC cases and 2340 controls were conducted. Seven SNPs in ITGA9 at 3p21.3 and 9 SNPs within the 6p21.3 HLA region were genotyped. To explore the potential clinical application of these genetic markers in NPC, we further evaluate the predictive/diagnostic role of significant SNPs by calculating the area under the curve (AUC). RESULTS: The reported associations between ITGA9…

• UD
  U.S. Department of Health and Human Services
• NN
  National Natural Science Foundation of China

  Awards: 30672377, HHSN26120080001E, 2010R50048
• NI
  National Institutes of Health

  Award: HHSN26120080001E
• NC
  National Cancer Institute

  Awards: 30672377, HHSN26120080001E, 2010R50048