p53 Regulates Mitochondrial Respiration
National Institutes of Health · Johns Hopkins University · +3 more institutions
Abstract
The energy that sustains cancer cells is derived preferentially from glycolysis. This metabolic change, the Warburg effect, was one of the first alterations in cancer cells recognized as conferring a survival advantage. Here, we show that p53, one of the most frequently mutated genes in cancers, modulates the balance between the utilization of respiratory and glycolytic pathways. We identify Synthesis of Cytochrome c Oxidase 2 (SCO2) as the downstream mediator of this effect in mice and human cancer cell lines. SCO2 is critical for regulating the cytochrome c oxidase (COX) complex, the major site of oxygen utilization in the eukaryotic cell. Disruption of the SCO2 gene in human cancer cells with wild-type p53…
Citation impact
- FWCI
- 40.79
- Percentile
- 100%
- References
- 31
Authors
9- SMSatoaki Matoba
National Institutes of Health, Johns Hopkins University, National Institute of Diabetes and Digestive and Kidney Diseases, National Heart Lung and Blood Institute, Sidney Kimmel Comprehensive Cancer Center
- JKJu‐Gyeong Kang
National Institutes of Health, Johns Hopkins University, National Institute of Diabetes and Digestive and Kidney Diseases, National Heart Lung and Blood Institute, Sidney Kimmel Comprehensive Cancer Center
- WDWillmar D. Patino
National Institutes of Health, Johns Hopkins University, National Institute of Diabetes and Digestive and Kidney Diseases, National Heart Lung and Blood Institute, Sidney Kimmel Comprehensive Cancer Center
- AWAndrew Wragg
National Institutes of Health, Johns Hopkins University, National Institute of Diabetes and Digestive and Kidney Diseases, National Heart Lung and Blood Institute, Sidney Kimmel Comprehensive Cancer Center
- MBManfred Boehm
National Institutes of Health, Johns Hopkins University, National Institute of Diabetes and Digestive and Kidney Diseases, National Heart Lung and Blood Institute, Sidney Kimmel Comprehensive Cancer Center
Topics & keywords
- Cytochrome c oxidase
- Warburg effect
- Glycolysis
- Biology
- Cancer cell
- Mitochondrion
- Cellular respiration
- Cell biology