Burnout and risk of cardiovascular disease: Evidence, possible causal paths, and promising research directions.
Tel Aviv University · Tel Aviv Sourasky Medical Center
Abstract
Burnout is characterized by emotional exhaustion, physical fatigue, and cognitive weariness, resulting from prolonged exposure to work-related stress. The authors review the accumulated evidence suggesting that burnout and the related concept of vital exhaustion are associated with increased risk of cardiovascular disease and cardiovascular-related events. The authors present evidence supporting several potential mechanisms linking burnout with ill health, including the metabolic syndrome, dysregulation of the hypothalamic-pituitary-adrenal axis along with sympathetic nervous system activation, sleep disturbances, systemic inflammation, impaired immunity functions, blood coagulation and fibrinolysis, and poor…
Citation impact
- FWCI
- 23.46
- Percentile
- 100%
- References
- 396
Authors
5Topics & keywords
- Burnout
- Disease
- Medicine
- Systemic inflammation
- Emotional exhaustion
- Fibrinolysis
- Sympathetic nervous system
- Inflammation
- No poverty