Redox Regulation of Cell Survival
Thammasat University · The University of Texas MD Anderson Cancer Center · +1 more institution
Abstract
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles in regulation of cell survival. In general, moderate levels of ROS/RNS may function as signals to promote cell proliferation and survival, whereas severe increase of ROS/RNS can induce cell death. Under physiologic conditions, the balance between generation and elimination of ROS/RNS maintains the proper function of redox-sensitive signaling proteins. Normally, the redox homeostasis ensures that the cells respond properly to endogenous and exogenous stimuli. However, when the redox homeostasis is disturbed, oxidative stress may lead to aberrant cell death and contribute to disease development. This review focuses on the…
Citation impact
- FWCI
- 20.27
- Percentile
- 100%
- References
- 356
Authors
5- DTDunyaporn Trachootham
Thammasat University, The University of Texas MD Anderson Cancer Center, University of Houston
- WLWeiqin Lu
The University of Texas MD Anderson Cancer Center, University of Houston
- MAMarcia A. Ogasawara
The University of Texas MD Anderson Cancer Center, University of Houston
- NRNilsa Rivera-Del Valle
The University of Texas MD Anderson Cancer Center, University of Houston
- PHPeng HuangCorresponding
The University of Texas MD Anderson Cancer Center, University of Houston
Topics & keywords
- Cell biology
- Transcription factor
- Oxidative stress
- Programmed cell death
- Reactive oxygen species
- Signal transduction
- Biology
- Homeostasis
- Good health and well-being