Cell Migration: Integrating Signals from Front to Back
University of North Carolina at Chapel Hill · The Royal Free Hospital · +10 more institutions
Abstract
Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mental retardation, atherosclerosis, and arthritis. The migrating cell is highly polarized with complex regulatory pathways that spatially and temporally integrate its component processes. This review describes the mechanisms underlying the major steps of migration and the signaling pathways that regulate them, and outlines recent advances investigating the nature of polarity in migrating cells and the pathways that establish it.
Citation impact
- FWCI
- 60.26
- Percentile
- 100%
- References
- 56
Authors
8- AJAnne J. RidleyCorresponding
University of North Carolina at Chapel Hill, The Royal Free Hospital, Ludwig Cancer Research, Prostate Cancer Research, UNC Lineberger Comprehensive Cancer Center, University College London, University of Virginia
- MAMartin A. Schwartz
University of North Carolina at Chapel Hill, The Royal Free Hospital, Ludwig Cancer Research, Prostate Cancer Research, Cardiovascular Research Center, Prostate Cancer Research Institute, UNC Lineberger Comprehensive Cancer Center, University College London, University of Virginia
- KBKeith Burridge
University of North Carolina at Chapel Hill, The Royal Free Hospital, Ludwig Cancer Research, Prostate Cancer Research, UNC Lineberger Comprehensive Cancer Center, University College London, University of Virginia
- RFRichard Firtel
University of North Carolina at Chapel Hill, The Royal Free Hospital, Ludwig Cancer Research, Prostate Cancer Research, UNC Lineberger Comprehensive Cancer Center, University College London, University of Virginia
- MHMark H. Ginsberg
University of North Carolina at Chapel Hill, Scripps Research Institute, The Royal Free Hospital, Ludwig Cancer Research, Prostate Cancer Research, UNC Lineberger Comprehensive Cancer Center, University College London, University of Virginia
Topics & keywords
- Cell polarity
- Cell migration
- Regeneration (biology)
- Morphogenesis
- Neuroscience
- Biology
- Embryonic stem cell
- Cell biology