Host Immune System Gene Targeting by a Viral miRNA
Hebrew University of Jerusalem · Hadassah Medical Center · +3 more institutions
Abstract
Virally encoded microRNAs (miRNAs) have recently been discovered in herpesviruses. However, their biological roles are mostly unknown. We developed an algorithm for the prediction of miRNA targets and applied it to human cytomegalovirus miRNAs, resulting in the identification of the major histocompatibility complex class I-related chain B (MICB) gene as a top candidate target of hcmv-miR-UL112. MICB is a stress-induced ligand of the natural killer (NK) cell activating receptor NKG2D and is critical for the NK cell killing of virus-infected cells and tumor cells. We show that hcmv-miR-UL112 specifically down-regulates MICB expression during viral infection, leading to decreased binding of NKG2D and reduced…
Citation impact
- FWCI
- 20.15
- Percentile
- 100%
- References
- 18
Authors
17- NSNoam Stern‐GinossarCorresponding
Hebrew University of Jerusalem, Hadassah Medical Center, Hadassah Academic College, University of Alabama at Birmingham, Heinrich Heine University Düsseldorf
- NENaama ElefantCorresponding
Hebrew University of Jerusalem, Hadassah Medical Center, Hadassah Academic College, University of Alabama at Birmingham, Heinrich Heine University Düsseldorf
- AZAlbert Zimmermann
Hebrew University of Jerusalem, Hadassah Medical Center, Hadassah Academic College, University of Alabama at Birmingham, Heinrich Heine University Düsseldorf
- DGDana G. Wolf
Hebrew University of Jerusalem, Hadassah Medical Center, Hadassah Academic College, University of Alabama at Birmingham, Heinrich Heine University Düsseldorf
- NSNivin Saleh
Hebrew University of Jerusalem, Hadassah Medical Center, Hadassah Academic College, University of Alabama at Birmingham, Heinrich Heine University Düsseldorf
Topics & keywords
- NKG2D
- microRNA
- Biology
- Human cytomegalovirus
- Major histocompatibility complex
- Gene
- Cytomegalovirus
- Virus
- Good health and well-being