articlePLoS ONENov 12, 2014GOLD OA

MicroRNA Related Polymorphisms and Breast Cancer Risk

SKSofia KhanDGDario GrecoKMKyriaki MichailidouRLRoger L. MilneTMTaru Muranen

University of Helsinki · Helsinki University Hospital · +103 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or in the miRNA binding sites may affect the miRNA dependent gene expression regulation, which has been implicated in various cancers, including breast cancer, and may alter individual susceptibility to cancer. We investigated associations between miRNA related SNPs and breast cancer risk. First we evaluated 2,196 SNPs in a case-control study combining nine genome wide association studies (GWAS). Second, we further investigated 42 SNPs with suggestive evidence for association using 41,785 cases and 41,880 controls from 41 studies included in the Breast Cancer Association Consortium (BCAC). Combining the GWAS and BCAC data…

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Topics & keywords

Topics
Keywords
  • Single-nucleotide polymorphism
  • Breast cancer
  • Drosha
  • Genome-wide association study
  • Odds ratio
  • microRNA
  • Case-control study
  • Oncology
UN Sustainable Development Goals
  • Good health and well-being
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