Decreased segregation of brain systems across the healthy adult lifespan
The University of Texas at Dallas · The University of Texas Southwestern Medical Center · +1 more institution
Abstract
Healthy aging has been associated with decreased specialization in brain function. This characterization has focused largely on describing age-accompanied differences in specialization at the level of neurons and brain areas. We expand this work to describe systems-level differences in specialization in a healthy adult lifespan sample (n = 210; 20-89 y). A graph-theoretic framework is used to guide analysis of functional MRI resting-state data and describe systems-level differences in connectivity of individual brain networks. Young adults' brain systems exhibit a balance of within- and between-system correlations that is characteristic of segregated and specialized organization. Increasing age is accompanied…
Citation impact
- FWCI
- 18.94
- Percentile
- 100%
- References
- 85
Authors
5- MYMicaela Y. ChanCorresponding
The University of Texas at Dallas
- DCDenise C. Park
The University of Texas at Dallas, The University of Texas Southwestern Medical Center
- NKNeil K. Savalia
The University of Texas at Dallas
- SESteven E. Petersen
Washington University in St. Louis
- GSGagan S. Wig
The University of Texas at Dallas, The University of Texas Southwestern Medical Center
Topics & keywords
- Human brain
- Neuroscience
- Brain function
- Healthy aging
- Measure (data warehouse)
- Biology
- Psychology
- Computer science